Results
| PMID | 22925688 |
| Gene Name | ABCG2 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | ABCG2 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2012 Dec;98(6):1512-20.e3. doi: 10.1016/j.fertnstert.2012.07.1133. Matsuzaki, Sachiko| Darcha, Claude CHU Clermont-Ferrand, CHU Estaing, Chirurgie Gynecologique, Clermont-Ferrand, France. sachikoma@aol.com OBJECTIVE: To investigate adenosine triphosphate (ATP)-binding cassette transporter G2 (ABCG2) expression in endometriosis and in samples of endometrium from patients with and without endometriosis. DESIGN: Prospective study. SETTING: University hospital. PATIENT(S): Patients with and without endometriosis. INTERVENTION(S): Endometrial and endometriotic tissues obtained throughout the menstrual cycle. MAIN OUTCOME MEASURE(S): Density of ABCG2(+) microvessels, density of CD31(+) microvessels. RESULT(S): No statistically significant differences in the density of ABCG2(+) microvessels were observed between endometrium of patients with and without endometriosis in the proliferative phase and early, middle, and late secretory phases. The density of ABCG2(+) microvessels was statistically significantly higher in the menstrual endometrium of patients with endometriosis compared with patients without endometriosis. The density of ABCG2(+) microvessels was reduced in the ectopic endometrium compared with matched eutopic endometrium except in cases of deep infiltrating endometriosis. The density of ABCG2(+) microvessels was statistically significantly higher in deep infiltrating endometriosis compared with ovarian endometriosis and red and black peritoneal lesions throughout the menstrual cycle. CONCLUSION(S): ABCG2 is strongly expressed in the endothelial cells of microvessels of eutopic endometrium, and the density of ABCG2(+) microvessels is reduced in ectopic endometrium except in cases of deep infiltrating endometriosis. ABCG2(+) microvessels may represent an integral part of the pathophysiology of deep infiltrating endometriosis. Mesh Terms: ATP Binding Cassette Transporter, Sub-Family G, Member 2| ATP-Binding Cassette Transporters/*metabolism| Endometriosis/*metabolism| Endometrium/*metabolism| Female| Humans| Neoplasm Proteins/*metabolism| Organ Specificity| Tissue Distribution|DA 2 |
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